SAN JOSE, Calif. -- The Panthers offensive line has been devastated by injuries this season, the latest coming with centers Ryan Kalil and Gino Gradkowski being placed on injured reserve Tuesday.With left tackle Michael Oher out for the year with a concussion and backup right tackle Daryl Williams nursing an injury, the Panthers may have even more problems protecting franchise quarterback Cam Newton on Sunday at Seattle.Kalil, a five-time Pro Bowl selection, missed three of the past four games before the Panthers placed him on injured reserve with a shoulder issue. It likely forces undrafted rookie Tyler Larsen to start at center against the Seahawks top-ranked defense.(Kalils) one of the best players at his position in the NFL. He might be the best center, Seahawks coach Pete Carroll said. So when you lose that caliber of player, you dont just lose the physical play, you lose the leadership and the smarts and all that.Panthers coach Ron Rivera said its going to be up to Larsen to help patch together a makeshift offensive line in noisy CenturyLink Field, where Carolina played the past two seasons, including the playoffs in 2014.Hes done a nice job for us, hes handled it very well, Rivera said. Im pretty excited about him getting his opportunity. ... I think were going to be fine.Larsen was signed as an undrafted free agent from Utah State, and has appeared in only three NFL games. He was released from Carolina on Oct. 8 before being brought back to the practice squad. The Panthers promoted him to the active roster Nov. 4.The Seahawks (7-3-1) have the NFLs top-ranked scoring defense, allowing 17 points a game. Theyll be looking for revenge after the Panthers ended their season in the 2015 divisional round playoff with a 31-24 decision in Charlotte.The Panthers elected to stay in the Bay Area this week to practice at San Jose State and cut down on travel time with consecutive games on the West Coast. Theyll prepare for Seattle on the same practice field they used before their loss in Super Bowl 50 to the Denver Broncos at nearby Levis Stadium.Carolina is coming off a defeat to the surging Raiders, 35-32, in a back-and-fourth game in Oakland. The Panthers took a 32-24 lead in the fourth quarter after falling behind 24-7 in the first half. But Oakland scored 10 points inside the final five minutes, dealing the Panthers (4-7) their fourth loss in five road games.Its been an unexpectedly turbulent season for Carolina after Newton was honored as the 2015 MVP following a 14-0 start.The teams regression can be traced to the slew of injuries along the offensive line. Only one player, left guard Andrew Norwell, is playing the same position where he began the season. Carolina credited good health for playing a role during the successful run to the Super Bowl. It hasnt lasted in 2016.Its a trickledown effect. It affects everything, tight end Greg Olsen said. Thats the nature of football. . . Last year was an anomaly with being relatively healthy throughout the season. It happens throughout the league. Its just sometimes the luck of the draw.Williams didnt practice Wednesday while he continued to sport a walking boot on his left foot after suffering an ankle injury late in the second quarter against the Raiders. If Williams cant play, the Panthers will likely have right guard Trai Turner play right tackle, where he hasnt started since high school.Game notes LB Luke Kuechly (concussion), WR Kelvin Benjamin (shoulder), S Kurt Coleman (concussion), DL Ryan Delaire (knee) did not practice Wednesday. ... The Panthers announced a $250,000 donation to high school athletic programs in North and South Carolina impacted by flooding and wind damage from Hurricane Matthew. The money is to assist in the replacement or repair of equipment, supplies or athletic infrastructure lost or damaged by the storm.---For more NFL coverage: http://www.pro32.ap.org and -- http://www.twitter.com/AP-NFLCustom Detroit Lions Jerseys . He was followed closely by David Clarkson, donning red, seconds later. Clarksons actions one night earlier, leaping off the bench in defence of Kessel during a pre-season game against the Buffalo Sabres, will cost him the first 10 games of the regular season. T.J. Hockenson Lions Jersey .Y. - Rob Manfred was promoted Monday to Major League Baseballs chief operating officer, which may make him a candidate to succeed Bud Selig as commissioner. http://www.lionsfanspro.com/Black-Kenny-Golladay-Lions-Jersey.html?cat=929 . 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He has recorded six consecutive quality outings, including a seven-inning performance at Seattle on Wednesday when he held the Mariners to one run.Matched against Mariners ace Felix Hernandez that night, Verlander wound up with a no-decision. Verlander, who hasnt lost since June 26 against the Cleveland Indians, could face a similar situation on Tuesday.Most pitchers, when their counterpart is well-known or one of the better pitchers in the league, it gives you a little more adrenaline, Detroit manager Brad Ausmus said. I think that probably happened when Verlander and Felix pitched against each other.Verlander ranks second in the America League in strikeouts with 170 and fourth in opponents batting average at .216.The Royals know all too well how effective Verlander can be. He has 22 career wins against them, the most by an active pitcher. He also won both of his starts against Kansas City this season while notching 17 strikeouts.Duffy isnt focused on the pitching matchup.Its fun competing against those guys in general, Duffy said. I dont look at who Im going up against because I dont have to get him out.Duffy (9-1, 2.82 ERA) was moved into the rotation on May 15 and has emerged as the RRoyals most reliable arm.dddddddddddd He is 9-1 with a 2.79 ERA as a starter, including his current eight-game winning streak. He recorded his first career complete game in his last start against the Chicago White Sox on Thursday.Ive been really simplified with everything. It sounds super boring, but thats just kind of where Im at, he said. Trust is crucial. Trusting your stuff and trusting whos behind you. I have all of that. I trust my stuff, and I trust my boys.Duffy is 4-6 with a 3.43 ERA in 16 career outings against Detroit, including four appearances this season.Hes always had great stuff, and he seems to have pitched well against us for the most part, Ausmus said. The big thing is hes really throwing strikes now. Hes always had a real good fastball, but hes throwing strikes and hes become what a lot of people thought he would be, a dominant left-handed starter.Ausmus club has been hit hard by injuries recently, and another one cropped up to a premier player on Monday. First baseman Miguel Cabrera left the Tigers 3-1 loss to the Royals prior to the fifth inning with a left biceps strain. He was injured reaching for an errant throw by starting pitcher Daniel Norris in the first inning.Ausmus considers the injury minor and said Cabrera might even return to the lineup for Tuesday nights game. Detroit already has three starting position players on the disabled list -- center fielder Cameron Maybin, third baseman Nick Castellanos and shortstop Jose Iglesias. ' ' '