CLEMSON, S.C. -- James Conners smile said it all -- Pittsburgh was happy to once again shuffle up the national championship picture.Hey, sorry to do that. But we wanted this one bad, said Conner, who had two touchdowns and ran for 132 yards in the Panthers 43-42 stunner over No. 3 Clemson on Saturday.Conners 20-yard TD run with 5:17 left inched the Panthers into striking range and Chris Blewitt -- after a kiss on the cheek from coach Pat Narduzzi -- struck a perfect, 48-yard field goal with six seconds left for the winning points.Well remember this one forever, Conner said.So, too, will Clemson (9-1, 6-1 Atlantic Coast Conference) which saw its run at perfection halted after escaping so many other jams this season. A fourth-down stop a yard shy saved the Tigers 42-36 win over No. 5 Louisville on Oct. 1. North Carolina States missed field goal at the end of regulation boosted Clemson to a 24-17 overtime win.This time, it was the Panthers (6-4, 3-3) who made the critical plays.When Clemson was driving for a touchdown already up 42-34, linebacker Saleem Brightwell picked off quarterback Deshaun Watson -- his third interception -- and returned it 70 yards to set up a 20-yard TD by Conner that drew Pitt within 42-40.When Clemson attempted to run out the clock, the Panthers defense (despite allowing 630 yards) stuffed Wayne Gallman a yard short on third and fourth downs to take over near midfield with 58 seconds left.We had a chance to put the game away and they stopped us, Clemson coach Dabo Swinney said. We had been making those kinds of plays this year.Nathan Peterman moved Pitt to the Clemson 30 and Blewitt steadily knocked through.It was Pitts highest-ranked win since defeating Backyard Brawl rival, No. 2 West Virginia, 13-9 in 2007 and spoiling the Mountaineers chances at playing for the national title.Our team had a lot of guts tonight, Narduzzi said.And a whole lot of playmakers to topple the defending ACC champs.Peterman had a career-best five TD passes and 308 yards. Conner rushed for 132 yards and a touchdown. He also caught one of Petermans scoring throws.Blewitt, who had a kick blocked at the end of the opening half, was steely eyed and ready. Narduzzi gave his senior a kiss on the cheek and sent him out for the winning kick.As soon as I saw the kick go up, I knew it was going in, Scott Orndoff said. It was jubilation.Clemson had its offense going. Watson threw for an ACC record 580 yards and three touchdowns. Gallman ran for three TDs and Mike Williams had 15 catches for 202 yards and a touchdown.In the end, it was Clemsons first loss to an unranked opponent in five seasons, a span of 46 games.Come Monday, well start over because its a long season, Watson said. Get ready for Wake Forest. Hopefully, we can clinch the ACC (Atlantic) and punch our ticket for the championship game next week.THE TAKEAWAYPittsburgh: The Panthers showed that Narduzzis program is taking hold. Peterman stayed calm in the face of Clemsons strong pass rush and Conner was able to avoid the Tigers middle duo of Carlos Watkins and Dexter Lawrence to keep Pitt moving.Clemson: Many non-Tiger fans will say this team had it coming after escaping with close wins at home against No. 5 Louisville (42-36 on Oct. 1) and North Carolina State (24-17 in overtime on Oct. 15) after the Wolfpack missed the potential game-winning kick to end regulation. Clemsons path is still clear -- win out and hope its one-loss season is better than most others.POLL IMPLICATIONSA rankings fall seemed likely for Clemson after the loss but that is likely to be mitigated by losses suffered by No. 2 Michigan and No. 4 Washington later in the day. After Wake Forest, the Tigers face revived rival South Carolina at Death Valley before potentially heading to Orlando, Florida, for the ACC championship game.RECORD DAYWatsons passing yards broke the 21-year-old mark of Wake Forests Rusty LaRue, who passed for 545 yards against North Carolina State on Nov. 18, 1995. Watson said the record doesnt console him after the loss. Id rather go 0-for-30 with no yards and get the W, he said.SAYING GOODBYEThis wasnt the farewell Clemsons offense wanted. Watson, Gallman, Williams and receiver Artavis Scott are all juniors who were honored with Clemsons seniors Saturday after Swinney said they would all be leaving the program for the NFL after this season. Watson acknowledged wild emotions. Still, Im going to keep a smile on my face, he said.UP NEXTPittsburgh closes the year with two games at home, starting with Duke next week.Clemson will try to earn the ACC Atlantic Division title with a win at Wake Forest next Saturday.---More AP college football: www.collegefootball.ap.orgBruce Matthews Womens Jersey . Galatasaray said in a statement on its website Monday that Mancini signed a three-year contract and will be paid 3.5 million euros for the upcoming season, with his salary upped to 4. Eddie George Womens Jersey . - Levi Browns tenure at left tackle for the Pittsburgh Steelers is over before it even began. http://www.titansstoreonline.com/Black-74-Bruce-Matthews-Womens-Jersey/ . Listen to the game live on TSN Radio 1050 at 7pm et. The Raptors traded Rudy Gay, Quincy Acy and Aaron Gray to the Sacramento Kings on Monday, in exchange for Greivis Vasquez, John Salmons, Patrick Patterson and Chuck Hayes. Jurrell Casey Womens Jersey . Pierce was ejected in the third quarter of Indianas 103-86 win Monday. George Hill stole a bad pass and was going in for a layup, and Pierce hustled back and appeared to be trying to wrap him up. Earl Campbell Titans Jersey . -- In one brief spurt, Brazil turned a close game into a rout and proved again it will be a strong World Cup favourite. SAN MARCOS, Texas -- Freshman Nijal Pearson scored 15 points and had five assists and Texas State used a big first-half run and a 50-31 rebounding advantage to pull away from Division II Oklahoma Panhandle State 75-44 on Thursday night.Maljhum McCrea scored 10 points, freshman Nedeljko Prijovic grabbed a season-high 13 rebounds and all 13 Bobcats who played scored at least a field goal.The Aggies twice led by seven points in the first half, but Texas State (4-3) rallied and Deris Duncans layup with 3:54 leftt sparked a 13-4 run and the Bobcats led 35-25 at halftime.dddddddddddd.Texas State led by as many as 35 points in the second half and finished shooting 43.1 percent from the floor (31 of 72). The Bobcats outscored the Aggies 50-20 in the paint and got 24 second-chance points off of 18 offensive rebounds.Malcolm Glanville scored 13 for OPSU, which counted it as an exhibition game. ' ' '