MINNEAPOLIS -- As a rookie with the New York Giants in 2004, a few weeks before taking over for good as the starting quarterback, Eli Manning was on the sideline while Kurt Warner helped lead a midseason victory at Minnesota.Most of the matchups with the Vikings since then havent gone so smoothly.In seven career starts against them, Manning has a 2-5 record with a rough 54.8 passer rating. Hes thrown for only five touchdowns, and five of the 14 interceptions by the Vikings have been taken to the end zone.Talking about having a guys number.I dont think anybody has my phone number on the Vikings, Manning said this week, using some wry humor to try to deflect the subject of his struggles.Hold on, he said, stringing along the joke in his session with reporters as if it were a hard fake handoff before dropping back to throw a play-action pass.Former Giants defensive tackle Linval Joseph, whos currently thriving in his role with Minnesota, might have the digits. Quarterbacks in the NFL form an unofficial fraternity, so perhaps Vikings starter Sam Bradford knows how to reach Manning.I cant think of anybody elses off hand, Manning said. Ill look at my phone and get back to you on that one, though.Vikings coach Mike Zimmer and his aggressive, versatile defense had Manning on his heels all night during a 49-17 victory in the cold last December after the Giants were eliminated from playoff contention.This year, the Vikings (3-0) lead the league with a plus-8 turnover margin. The Giants (2-1) are tied for the second-worst at minus-6.The Vikings were greatly aided last season by the absence of wide receiver Odell Beckham Jr., who served a suspension for his on-field antics the week before. Beckhams behavior has been a hot topic again this year , and coach Ben McAdoo chided him about the distraction, but his performance hasnt left much to be desired. He hasnt scored a touchdown yet, but he has 280 yards on 19 receptions.Zimmer expressed concern beyond Beckham. Rookie Sterling Shepard and the resurgent Victor Cruz have given Manning a dangerous downfield trio.It puts a lot of stress on you, because youve got to cover the field, the coach said. Its not like you can cheat very much.Here are some other key angles to know about the game:KEEPING QUIET: Beckham, including last week against Washington, has had two well-publicized edgy matchups with the equally intense cornerback Josh Norman. Dont expect any of Minnesotas defensive backs to engage in any similar trash talking, though.We try to do things a certain way here. We try to play smart football, do things right, Zimmer said. Obviously, we try to win the game the best way we can, but were not into that other stuff.RUNNING ROOM?: The Vikings, whove turned to Jerick McKinnon and Matt Asiata with Adrian Peterson likely finished for the season, are last in the NFL in yards rushing. The Giants have given up the fifth-fewest yards on the ground.If we can find something to kind of spark the run game and get it going, Bradford said, I think it can only help us.WHOS CARRYING THE BALL?: Giants starting running back Rashad Jennings injured his left thumb in the second game and sat out last week, when backup Shane Vereen tore a triceps muscle in his place and was lost for the season. While Jennings is on track to return this week, the Giants also might have to turn to Orleans Darkwa, Bobby Rainey or rookie Paul Perkins. Only Darkwa has carries this year, having run 10 times for 53 yards and a touchdown in the last game against Washington.SECONDARY STRUGGLE: Starting free safety Darian Thompson, who missed last weeks game with a foot injury, was still wearing a boot on Wednesday. The rookie didnt practice on Thursday. Nat Berhe, who started in his place against Washington, was placed in the concussion protocol after reporting to the Giants on Tuesday with a headache. He was held out of practice on Thursday, too. That left nickel cornerback Leon Hall mixing in with Andrew Adams, who made his NFL debut last Sunday, next to strong safety Landon Collins.The cornerbacks also are hurting with Dominique Rodgers-Cromartie (groin) and his backup Eli Apple (hamstring) both forced out of the last game. Neither of them participated in practice on Thursday, either.When we have a change in the defense, I definitely step up, Collins said. I dont just stay settled because we need playmakers.MONDAY NIGHT MUSINGS: This will be the first Monday night home game for the Vikings since Oct. 5, 2009, against Green Bay. Theyve faced the Giants five times on Monday night, most recently on the road on Oct. 21, 2013. 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BOSTON -- Louisville will eventually need some help to get back into the College Football Playoff conversation.In the meantime, the fifth-ranked Cardinals (7-1, 5-1 ACC) would help themselves out a lot by showing the committee they are still the dominant offense they were earlier this season.Saturdays matchup with Boston College (4-4, 1-4), which has the conferences top-ranked defense, would go a long way toward that.Despite needing a late touchdown to avoid an upset at Virginia last week, Louisville still has the nations top-ranked offense, scoring 50 points per game. Heisman Trophy candidate Lamar Jackson is also showing no signs of slacking off, with 38 total touchdowns on the season.But running back Brandon Radcliff said one thing last week taught them is that no team is going to lay down for them.We hear a lot of defenses they say are aggressive or whatnot, but we take everybody the same, he said. We cant take one opponent lightly because we could be in a dogfight in a minute.The Cardinals have won the last three meetings with the Eagles, but have split the four meetings at BCs Alumni Stadium. A Cardinals victory would mark the first time Louisville has started 8-1 since 2013.In last years meeting, which Louisville won 17-14, Boston Colleges defense was able to hold Jackson to just 15 yards on 14 carries and one rushing touchdown. It was the Cardinals defense that came up big, scoring off a 45-yard fumble return.Boston College coach Steve Addazio said he expects Jackson to be a lot more difficult to contain this year, but his team cant just focus on containing the quarterback.I think thats the problem for everybody right now, Addazio said. You have to have your focus on him, but when you do that, youre in trouuble all over the field.ddddddddddddHere are some other things to watch for on Saturday:FINDING CONFIDENCEAddazio said the biggest thing that came out Boston College breaking its ACC drought at N.C. State last week -- the Eagles first conference win since 2014 -- was that his young team gained some much-needed confidence.Its been hard and frustrating as we develop this team, but I love this team and believe in this team completely, Addazio said. While thats one game, and while we know what we have ahead of us here, we also know that what we see is real and it validates.LANDRYS WORLDThe Eagles will need a big effort from defensive end Harold Landry if they are going to slow down the Cardinals attack. Last weeks co-ACC defensive player of the week is putting up some of the best numbers of his career this season. He currently is tied for the national lead for sacks with nine, and also is tied for the NCAA lead with five forced fumbles. He has recorded 29 tackles on the year and 11 tackles for a loss.MILESTONE WATCHJackson enters the game with 3,520 yards of total offense on the season to go with 38 total touchdowns (22 passing, 16 rushing). He is 4 yards short of becoming the first quarterback in school history to rush for 1,000 yards in a season.NUMBERS GAMEThe Cardinals have scored at least 50 points five times in 2016. BCs defense has been stout, but has let a few games get away. The Eagles lost 49-0 at Virginia Tech in September and 56-10 to Clemson last month.---More AP college football: http://collegefootball.ap.org---Follow Kyle Hightower on Twitter at http://www.twitter.com/khightower ' ' '